Test library
MDI Specific IgE Test
The MDI Allergy Test measures IgE antibodies to methylene diphenyl diisocyanate, a chemical used in rigid foams and binders. It helps assess sensitization when respiratory or skin symptoms follow workplace exposure.
Order Isocyanate MDI Allergy Test
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order Isocyanate MDI Allergy Test- Typical turnaround
- 1-3 business days
- Starting price
- From $49
- Results
- Confidential, online
Quick answer
The MDI Allergy Test detects IgE antibodies against methylene diphenyl diisocyanate, one of the main isocyanate chemicals used in industry. MDI is found in rigid polyurethane foams, binders, and insulation. Repeated exposure can sensitize the immune system and contribute to work-related asthma or skin reactions, and this test helps determine whether MDI is part of that picture.
What this test measures
Methylene diphenyl diisocyanate, commonly called MDI, is a reactive chemical used to make rigid foams, binders, and composite materials. It is present in insulation, furniture, automotive parts, and construction products. Exposure can occur during manufacturing, spraying, and handling of uncured material.
The test measures specific IgE antibodies against MDI in a blood sample. A detectable level means the immune system has been sensitized to the chemical, which is more common among people with regular occupational exposure. Sensitization increases the chance that exposure is contributing to symptoms, although it does not confirm a diagnosis by itself.
Construction workers, foam manufacturers, and others who work with MDI-containing products may be tested when they develop wheezing, nasal symptoms, or dermatitis that follows work exposure. A qualified healthcare provider should interpret the result together with the work history and any breathing tests.
- MDI-specific IgE antibodies
- Quantitative sIgE concentration reported in kU/L
- Allergen-specific IgE class on a graded scale
- Total serum IgE when included
- Blood eosinophil count when included
- Related isocyanate markers such as HDI or TDI when a panel is ordered
Why people order this test
- Assess sensitization after exposure to MDI-based foams and binders
- Help evaluate work-related asthma-like or skin symptoms
- Add objective information to an occupational health assessment
- Support a clinician's recommendations about exposure control
- Check a single isocyanate when a broader panel is not needed
- Provide context for symptoms that improve away from work
How to prepare
No fasting is required for this blood test. Follow the collection instructions provided by the laboratory, and be ready to describe the materials and tasks associated with the symptoms being evaluated.
Understanding your results
Results are usually available within one to three business days. A detectable MDI-specific IgE level indicates sensitization to the chemical, but sensitization and symptoms do not always occur together, and some reactions have other mechanisms. A qualified healthcare provider should interpret the findings.
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Frequently Asked Questions
What is MDI?
MDI stands for methylene diphenyl diisocyanate, a reactive chemical used to produce rigid polyurethane foams, binders, and composite materials.
Which jobs involve MDI exposure?
Construction, insulation, furniture and panel manufacturing, automotive parts production, and other industries that use polyurethane materials can involve MDI exposure.
What does a positive result mean?
It means the immune system has been sensitized to MDI. When work-related symptoms are present, this supports further evaluation by a healthcare provider.
Does a negative result rule out MDI as a cause?
No. Not all reactions are IgE-mediated, and a negative test does not exclude an occupational cause. A clinician can assess exposure, symptoms, and other tests.
Can MDI and other isocyanates be tested together?
Yes. Isocyanate panels can include HDI, MDI, and TDI in a single blood sample when multiple exposures are possible.
Ready to get tested?
Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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