Isocyanate MDI Antibody Test in Alaska

What this test measures

Methylene diphenyl diisocyanate, commonly called MDI, is a reactive chemical used to make rigid foams, binders, and composite materials. It is present in insulation, furniture, automotive parts, and construction products. Exposure can occur during manufacturing, spraying, and handling of uncured material.

The test measures specific IgE antibodies against MDI in a blood sample. A detectable level means the immune system has been sensitized to the chemical, which is more common among people with regular occupational exposure. Sensitization increases the chance that exposure is contributing to symptoms, although it does not confirm a diagnosis by itself.

Construction workers, foam manufacturers, and others who work with MDI-containing products may be tested when they develop wheezing, nasal symptoms, or dermatitis that follows work exposure. A qualified healthcare provider should interpret the result together with the work history and any breathing tests.