Test library
SHBG Level Test
The SHBG blood test measures sex hormone binding globulin, a protein that binds testosterone and estrogens and affects how much hormone is free to act. It is used in the evaluation of hormone imbalances and related conditions.
Order SHBG (Sex Hormone Binding Globulin) Levels Blood Test
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order SHBG (Sex Hormone Binding Globulin) Levels Blood Test- Typical turnaround
- 1-3 business days
- Starting price
- From $138
- Results
- Confidential, online
Quick answer
The SHBG blood test measures the level of sex hormone binding globulin in the blood. SHBG is a liver-produced protein that attaches to testosterone, dihydrotestosterone, and estrogens, controlling how much of these hormones remain free and biologically active. It is ordered when a hormone imbalance is suspected or when total hormone levels need context. Results are interpreted by a qualified healthcare provider.
What this test measures
Sex hormone binding globulin is made in the liver and circulates in the bloodstream. It binds tightly to testosterone, dihydrotestosterone, and estradiol, and only the unbound fraction of these hormones is available to act on tissues. Measuring SHBG helps clinicians estimate free hormone levels and better understand symptoms such as low libido, fatigue, or changes in body composition.
The test requires a blood sample, usually drawn from a vein. SHBG is often ordered alongside total testosterone, estradiol, or other hormones. Levels can be influenced by thyroid function, liver health, body weight, insulin resistance, and certain medications, so the result is rarely interpreted in isolation.
SHBG testing is used in the evaluation of conditions such as polycystic ovary syndrome, thyroid disorders, liver disease, and disorders of androgen excess or deficiency. It can also help monitor the effects of hormone therapy. The test does not diagnose a condition by itself and should be reviewed with the broader clinical picture.
- Sex hormone binding globulin (SHBG)
- Total testosterone
- Free testosterone, calculated or measured
- Estradiol
- Dihydrotestosterone (DHT)
- Albumin
- Luteinizing hormone (LH)
- Follicle-stimulating hormone (FSH)
Why people order this test
- Evaluate suspected testosterone deficiency or excess
- Investigate symptoms of hormone imbalance
- Assess free hormone levels alongside total testosterone
- Support the workup of polycystic ovary syndrome
- Monitor hormone therapy or changes in liver or thyroid function
- Clarify abnormal menstrual or fertility symptoms
How to prepare
A blood sample is collected from a vein, usually at the arm. Fasting may be requested if the test is combined with glucose, insulin, or lipid tests. Follow the timing and preparation instructions provided with the order.
Understanding your results
Results are typically available within one to three business days. The report shows the SHBG level, often with related hormone values. High or low SHBG changes the amount of free hormone available, and a qualified healthcare provider interprets the numbers with symptoms and other findings.
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Frequently Asked Questions
What is SHBG?
SHBG is a protein made by the liver that binds testosterone and estrogens in the blood, affecting how much hormone is free to act on tissues.
Why is SHBG tested?
It helps clinicians understand free hormone levels and is used in the evaluation of conditions affecting thyroid, liver, and reproductive health.
Does the test require fasting?
Fasting is not always required. It may be requested if SHBG is ordered with glucose, insulin, or lipid tests.
Can medications change SHBG levels?
Yes. Some hormones, thyroid medications, and other drugs can raise or lower SHBG. Sharing a medication list helps with interpretation.
Is a high or low SHBG result a diagnosis?
No. SHBG is one piece of the picture. A healthcare provider interprets it alongside other hormone tests and the clinical history.
Ready to get tested?
Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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