Test library
Infectious Mononucleosis Antibody Test
The Mono Test detects antibodies associated with infectious mononucleosis, which is often caused by the Epstein-Barr virus. It helps evaluate symptoms such as fatigue, fever, and sore throat.
Order Mono Test (Mononucleosis) - Blood Testing
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order Mono Test (Mononucleosis) - Blood Testing- Typical turnaround
- 1-3 business days
- Starting price
- From $49
- Results
- Confidential, online
Quick answer
The Mono Test checks a blood sample for antibodies associated with infectious mononucleosis, a condition most often caused by the Epstein-Barr virus. Mono can produce prolonged fatigue, fever, sore throat, and swollen lymph nodes. Testing helps distinguish it from other illnesses with similar symptoms. Different antibody markers can also show whether an infection is current or occurred in the past.
What this test measures
Infectious mononucleosis is commonly caused by Epstein-Barr virus, which spreads mainly through saliva. The immune system responds by producing antibodies, and laboratory testing looks for these markers. A rapid heterophile antibody test is often used first, while more specific EBV antibody tests can clarify the stage of infection when needed.
EBV antibody testing may include viral capsid antigen IgM and IgG, along with nuclear antigen IgG. The pattern of these markers helps a provider tell whether the infection is recent, ongoing, or from the past. A complete blood count and liver enzyme tests are sometimes included because mono can affect those values.
People may order this test when symptoms suggest mono, when fatigue persists without a clear cause, or to follow up on an earlier result. A qualified healthcare provider interprets the antibody pattern with the person's symptoms and timing. Rest and return-to-activity decisions are medical matters for that provider.
- Heterophile antibodies
- Epstein-Barr virus capsid antigen IgM
- Epstein-Barr virus capsid antigen IgG
- Epstein-Barr virus nuclear antigen IgG
- Complete blood count components when included
- Liver enzyme markers when included
Why people order this test
- Evaluate symptoms that suggest infectious mononucleosis
- Distinguish a current infection from a past one
- Support a workup for persistent fatigue
- Follow up on an earlier mono test result
- Check related blood count and liver markers when included
How to prepare
No fasting is required for this blood test. Follow the collection instructions provided by the laboratory, and tell the collection staff about any medications you take and when your symptoms began.
Understanding your results
Results are typically available within one to three business days. The antibody pattern helps show whether an infection is current or past. A qualified healthcare provider interprets the findings with your symptoms and may repeat testing if the timing was early.
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Frequently Asked Questions
What does the mono test detect?
It detects antibodies associated with infectious mononucleosis, including heterophile antibodies and, when included, specific Epstein-Barr virus antibodies.
Can the test show a past infection?
Yes. Certain EBV antibody patterns indicate an infection from the past, while others suggest a recent or current infection.
Why can the test be negative early in the illness?
Antibodies take time to develop, so testing too soon after symptoms begin can miss them. A provider may recommend repeat testing later.
Is mono the same as strep throat?
No. They are different conditions with overlapping symptoms. Testing helps tell them apart so the right management plan can be made.
Do I need to fast for this test?
No. Fasting is not required for mono antibody testing. Follow any specific instructions on your laboratory order.
Ready to get tested?
Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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