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Kidney and Liver Function Panel

Kidney and Liver Tests combine blood and urine markers that assess how these organs filter, process, and clear substances. They are often ordered together when a medication, condition, or set of symptoms can affect both organs.

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Quick answer

Kidney and Liver Tests are panels that measure markers of two organs that work together to filter blood, process nutrients, and clear waste and medications. Because the kidneys and liver are both exposed to substances absorbed from the digestive tract and circulating in the blood, they are commonly checked together. The results help assess organ function, screen for early changes, and monitor conditions or treatments that can affect either organ.

What this test measures

The kidneys filter waste and excess fluid from the blood and produce urine. The liver processes nutrients, breaks down medications and toxins, and makes proteins and bile. Each organ has its own laboratory markers, and checking both gives a broader view of how the body is handling internal and external substances.

For the kidneys, common markers include creatinine, eGFR, blood urea nitrogen, and urine albumin. For the liver, common markers include alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, and albumin. A combined panel reports these values with reference ranges. Results are read together to build a complete picture.

A provider may order combined testing when reviewing medications that affect both organs, when evaluating a cluster of symptoms such as fatigue, swelling, or changes in urine or stool color, or as part of a general health assessment. Results are interpreted together because findings in one organ can influence the other. A qualified healthcare provider should evaluate the findings.

  • Serum creatinine and estimated glomerular filtration rate
  • Blood urea nitrogen (BUN)
  • Urine albumin or urinalysis components
  • Alanine aminotransferase (ALT)
  • Aspartate aminotransferase (AST)
  • Alkaline phosphatase (ALP)
  • Bilirubin
  • Albumin and total protein when included

Why people order this test

  • Assess both organs when symptoms overlap
  • Monitor medications that can affect the kidneys or liver
  • Support a general health or metabolic evaluation
  • Follow known kidney or liver conditions over time
  • Investigate fatigue, swelling, or changes in urine or stool
  • Establish baseline values before starting certain treatments
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How to prepare

Some clinicians ask for a period of fasting before combined kidney and liver testing, while others do not require it. Follow the instructions provided with the order, and avoid alcohol or strenuous exercise beforehand if the laboratory advises it.

Understanding your results

Results are usually available within one to three business days. Each marker is reported with a reference range, and results are interpreted as a pattern rather than as single values. A qualified healthcare provider should explain the findings and whether monitoring or follow-up is needed.

Kidney and Liver Function Panel by state

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Frequently Asked Questions

Why are kidney and liver tests ordered together?

Many conditions, medications, and general health assessments can affect both organs. Testing them together gives a more complete picture of how the body is filtering and processing substances.

Do I need to fast for this panel?

Some providers request fasting and others do not. Follow the instructions supplied with the test order, and ask the laboratory if you are unsure.

What do elevated liver enzymes mean?

Elevated liver enzymes can have many causes, including medications, alcohol, infections, and metabolic conditions. A healthcare provider evaluates the pattern and the clinical context.

Can medications affect these results?

Yes. Many prescription and over-the-counter medications can influence kidney and liver markers, so sharing a medication list with the testing provider is helpful.

How often should these tests be repeated?

The interval depends on the reason for testing, the results, and any treatment being monitored. A healthcare provider sets the appropriate schedule.

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Every page on this site is reviewed for clarity, sourcing, and accuracy. We update our library as testing options, collection networks, and accreditation standards change.

Medical disclaimer. The information on LabOrdering.com is educational only and is not medical advice, diagnosis, or treatment. Reference ranges and clinical guidance vary between laboratories. Always consult a qualified healthcare provider about your own results and care.