Test library
TDI Sensitization Blood Test
The TDI Allergy Test measures IgE antibodies to toluene diisocyanate, a chemical used in flexible foams. It helps assess sensitization when asthma-like or skin symptoms follow workplace exposure.
Order Isocyanate TDI Allergy Test
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order Isocyanate TDI Allergy Test- Typical turnaround
- 1-3 business days
- Starting price
- From $49
- Results
- Confidential, online
Quick answer
The TDI Allergy Test detects IgE antibodies against toluene diisocyanate, a volatile isocyanate used mainly to produce flexible polyurethane foam. TDI is a recognized cause of occupational asthma, and symptoms may begin after weeks or months of exposure. The test helps show whether an allergic sensitization to TDI is present when work-related symptoms are being investigated.
What this test measures
Toluene diisocyanate, or TDI, is a reactive chemical used in flexible foams for furniture, mattresses, and automotive seating. It can also be present in coatings and sealants. Because TDI can become airborne during production and handling, inhalation is a common route of exposure.
The test measures specific IgE antibodies to TDI from a blood sample. A positive result shows sensitization, which is more likely with repeated exposure. Some people develop asthma-like symptoms after sensitization, while others remain without symptoms, so results are interpreted with the clinical history.
People who manufacture or handle flexible foam, or who work with TDI-based products, may be tested when they report wheezing, cough, chest tightness, or skin irritation that appears at work. A qualified healthcare provider should interpret the result and consider breathing tests or other evaluation.
- TDI-specific IgE antibodies
- Quantitative sIgE concentration reported in kU/L
- Allergen-specific IgE class on a graded scale
- Total serum IgE when included
- Blood eosinophil count when included
- Related isocyanate markers such as HDI or MDI when a panel is ordered
Why people order this test
- Assess sensitization after exposure to TDI-based flexible foams
- Help evaluate work-related asthma-like or skin symptoms
- Add objective information to an occupational health assessment
- Support a clinician's recommendations about exposure control
- Check a single isocyanate when a broader panel is not needed
- Provide context for symptoms that improve away from work
How to prepare
No fasting is required for this blood test. Follow the collection instructions provided by the laboratory, and be ready to describe the materials and tasks associated with the symptoms being evaluated.
Understanding your results
Results are usually available within one to three business days. A detectable TDI-specific IgE level indicates sensitization to the chemical, but not everyone who is sensitized develops symptoms, and other mechanisms can also cause workplace reactions. A qualified healthcare provider should interpret the findings.
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Frequently Asked Questions
What is TDI?
TDI stands for toluene diisocyanate, a volatile isocyanate chemical used mainly to make flexible polyurethane foam.
Why is TDI associated with occupational asthma?
TDI can become airborne during foam production and handling. Repeated inhalation exposure can sensitize the airways and lead to asthma-like symptoms in some workers.
What does a positive result mean?
It means the immune system has been sensitized to TDI. This supports further evaluation when symptoms follow workplace exposure.
Can symptoms start long after exposure begins?
Yes. Sensitization can develop after weeks or months of regular exposure, and symptoms may appear gradually or after a specific higher-exposure episode.
Is a blood test enough to diagnose occupational asthma?
No. Diagnosis usually combines the exposure history, symptoms, lung function testing, and sometimes other tests. IgE testing is one part of the evaluation.
Ready to get tested?
Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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