Test library
IBD Blood Test
The Inflammatory Bowel Disease Test checks blood markers such as ASCA and p-ANCA that can support the evaluation of Crohn's disease and ulcerative colitis alongside imaging, endoscopy, and clinical findings.
Order Inflammatory Bowel Disease (IBD) Test
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order Inflammatory Bowel Disease (IBD) Test- Typical turnaround
- 1-3 business days
- Starting price
- From $298
- Results
- Confidential, online
Quick answer
The Inflammatory Bowel Disease Test is a blood test that measures antibodies and inflammatory markers associated with Crohn's disease and ulcerative colitis. These conditions cause persistent inflammation of the digestive tract, and their symptoms can overlap with other disorders. The test is used to add information to the clinical picture, while diagnosis usually depends on endoscopy, imaging, and sometimes biopsy.
What this test measures
Inflammatory bowel disease includes Crohn's disease and ulcerative colitis, two chronic conditions with different patterns of inflammation. The immune system plays a central role, and certain antibodies appear more often in one form than the other. Serologic testing looks for those antibody patterns and, in some panels, for general markers of inflammation.
Common markers include anti-Saccharomyces cerevisiae antibodies, known as ASCA, and perinuclear anti-neutrophil cytoplasmic antibodies, known as p-ANCA. Other antibodies such as anti-OmpC, anti-CBir1, and anti-I2 may be included in expanded panels. Inflammatory proteins such as C-reactive protein and fecal calprotectin may be added depending on the order.
The test may be ordered for someone with ongoing diarrhea, abdominal pain, weight loss, or blood in the stool when a provider is evaluating possible IBD. Results can support a direction of inquiry but cannot confirm or exclude the disease on their own, because markers overlap and some people with IBD have normal results. A qualified healthcare provider should interpret the findings.
- Anti-Saccharomyces cerevisiae antibodies (ASCA) IgG
- Anti-Saccharomyces cerevisiae antibodies (ASCA) IgA
- Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA)
- Atypical p-ANCA
- Anti-OmpC antibodies
- Anti-CBir1 flagellin antibodies
- Anti-I2 antibodies
- C-reactive protein when included
- Fecal calprotectin when included
Why people order this test
- Support the evaluation of persistent digestive symptoms
- Add antibody information when IBD is part of a differential
- Help distinguish patterns associated with Crohn's disease or ulcerative colitis
- Follow up abnormal inflammatory markers with a clinician
- Provide context for someone with a family history of IBD
- Assist in selecting which further tests may be appropriate
How to prepare
No fasting is usually required for the blood portion of this test. If a stool marker such as calprotectin is included, follow the separate stool collection instructions provided by the laboratory.
Understanding your results
Results are usually available within one to three business days. Certain antibody patterns are more common in Crohn's disease or ulcerative colitis, but none of them confirms a diagnosis, and results can overlap between conditions. A qualified healthcare provider should interpret the panel with endoscopy, imaging, and clinical findings.
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Frequently Asked Questions
Can this blood test diagnose IBD?
No. The test supports the evaluation by showing antibody and inflammation patterns. A diagnosis is made with clinical assessment, endoscopy, imaging, and often biopsy.
What is the difference between Crohn's disease and ulcerative colitis?
Both are chronic inflammatory conditions, but they affect different parts of the digestive tract and have different patterns. Antibody markers can suggest one pattern over the other.
Can results be normal if I have IBD?
Yes. Some people with IBD do not have the antibodies measured by this panel, so normal results do not rule out the condition.
Who usually orders this test?
It is commonly ordered by gastroenterologists, primary care providers, or other clinicians evaluating chronic digestive symptoms and considering IBD.
Does the test require a stool sample?
The core serology uses blood. Some panels also include a stool marker such as calprotectin, which requires a separate stool sample.
Ready to get tested?
Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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