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High-Risk HPV Test

The Human Papillomavirus Test detects genetic material from high-risk HPV types in a collected sample. It is used in cervical screening and follow-up, since persistent high-risk HPV infection is linked to cervical cell changes.

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Typical turnaround
1-3 business days
Starting price
From $219
Results
Confidential, online

Quick answer

The Human Papillomavirus Test is a laboratory test that looks for the genetic material of high-risk HPV types. HPV is a very common virus with many types, and a small number of high-risk types are linked to cervical cell changes and other cancers. The test is used most often in cervical screening, sometimes together with a Pap test, and results are interpreted with the person's screening history.

What this test measures

HPV spreads through skin-to-skin sexual contact and is common in sexually active adults. Most infections clear on their own within a year or two without causing any problems. When a high-risk type persists, it can lead to changes in cervical cells that may progress over time, which is why screening programs look for these types in particular.

The test detects HPV DNA or RNA from a collected sample. Depending on the service, the sample may be collected from the cervix by a clinician, collected as a swab, or provided as a urine sample where that option is offered. Many tests report whether high-risk types are present and may specify genotypes 16 and 18, which carry the highest risk, or group the remaining high-risk types together.

Screening programs recommend testing at intervals based on age, history, and prior results. A positive high-risk HPV result does not mean a person has cancer; it means the virus is present and follow-up or repeat testing may be needed. A qualified healthcare provider should explain what a result means and what the recommended next step is for that individual.

  • High-risk HPV DNA or RNA
  • HPV type 16
  • HPV type 18
  • Other high-risk HPV genotypes such as 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68
  • Low-risk HPV genotypes when included
  • Cytology co-test markers when paired with a Pap specimen

Why people order this test

  • Routine cervical screening for high-risk HPV types
  • Follow-up after an abnormal Pap or prior HPV result
  • Clarify whether a persistent high-risk infection is present
  • Support screening decisions in people with a history of cervical changes
  • Provide information before a discussion about vaccination or follow-up
  • Investigate selected symptoms when a clinician considers HPV testing appropriate
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How to prepare

No fasting is required. The collection method depends on the test ordered and the service used, so follow the sample collection instructions provided by the clinic or laboratory.

Understanding your results

Results are usually available within one to three business days, depending on the laboratory and collection method. A negative result means the tested high-risk types were not detected, while a positive result means the virus is present but does not mean cancer is present. A qualified healthcare provider can explain what follow-up timing is appropriate.

High-Risk HPV Test by state

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Frequently Asked Questions

What is the difference between an HPV test and a Pap test?

A Pap test looks for changes in cervical cells, while an HPV test looks for the virus that can cause those changes. They are often used together in screening.

Can HPV infection be cured?

There is no treatment that targets the virus itself, but most infections clear without intervention. Follow-up focuses on detecting cell changes that may need attention.

Does a positive HPV result mean I have cancer?

No. A positive result means high-risk HPV is present. Most infections do not lead to cancer, and follow-up testing is used to monitor for cell changes.

Can men be tested for HPV?

Routine HPV testing is not currently recommended for men. HPV-related concerns in men are usually evaluated through a clinical examination.

Does the HPV vaccine affect test results?

The vaccine protects against certain types and does not treat an existing infection. It can reduce the chance of infection with the types it covers, but screening recommendations still apply.

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Every page on this site is reviewed for clarity, sourcing, and accuracy. We update our library as testing options, collection networks, and accreditation standards change.

Medical disclaimer. The information on LabOrdering.com is educational only and is not medical advice, diagnosis, or treatment. Reference ranges and clinical guidance vary between laboratories. Always consult a qualified healthcare provider about your own results and care.