Test library
Homocysteine Cardiac Risk Test
The homocysteine test measures the level of homocysteine, an amino acid, in the blood. Elevated levels have been associated with cardiovascular risk and can also reflect certain vitamin deficiencies.
Order Homocysteine Levels Test
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order Homocysteine Levels Test- Typical turnaround
- 1-3 business days
- Starting price
- From $136
- Results
- Confidential, online
Quick answer
The homocysteine test measures the amount of homocysteine in the blood. Homocysteine is an amino acid produced during normal metabolism, and its level depends partly on vitamins B12, B6, and folate. Higher levels have been linked to cardiovascular and blood vessel concerns, so the test is sometimes ordered alongside other heart risk markers or when a vitamin deficiency is suspected.
What this test measures
Homocysteine is formed as the body processes the amino acid methionine. Vitamins B12, B6, and folate help convert it into other substances, so a shortage of these vitamins can raise homocysteine levels. Measuring homocysteine can therefore provide clues about both cardiovascular risk and nutritional status.
The test uses a blood sample drawn from a vein. Because homocysteine can rise after a protein-rich meal, some laboratories prefer a fasting sample. Results are reported as a concentration and compared with a reference range that varies by laboratory and population.
An elevated homocysteine level is a risk marker, not a diagnosis of heart disease. Clinicians interpret it together with cholesterol, blood pressure, kidney function, and other factors. Anyone with an abnormal result should discuss its meaning and appropriate follow-up with a qualified healthcare provider.
- Homocysteine (total)
- Vitamin B12
- Folate (folic acid)
- Vitamin B6
- Methylmalonic acid when included
- Serum creatinine
- Estimated glomerular filtration rate when paired
Why people order this test
- Assess cardiovascular risk alongside other markers
- Evaluate a possible vitamin B12 or folate deficiency
- Follow up on an abnormal homocysteine result
- Monitor levels in people with known metabolic concerns
- Support investigation of unexplained blood vessel problems
- Provide context before a provider discussion about risk
How to prepare
Fasting may be requested for this test because homocysteine can rise after eating. A blood sample is drawn from a vein, usually at the arm. Follow the specific instructions provided with the order.
Understanding your results
Results are typically available within one to three business days. The report shows the homocysteine concentration and the laboratory reference range. An elevated value is a risk marker that a healthcare provider interprets with other findings.
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Frequently Asked Questions
What is homocysteine?
It is an amino acid made during normal metabolism. Its level is influenced by vitamins B12, B6, and folate, and higher levels have been linked to cardiovascular risk.
Do I need to fast before this test?
Fasting may be requested because eating protein can raise homocysteine. Follow the laboratory's specific instructions for the order.
What causes high homocysteine?
Low levels of vitamins B12, B6, or folate are common contributors. Kidney function and some medications can also affect the level, which a provider evaluates.
Is a high result a diagnosis?
No. An elevated homocysteine is a risk marker. It is interpreted together with other tests and the person's overall health by a qualified provider.
Ready to get tested?
Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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