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Hepatitis B Antibody Status Test

A blood test that checks hepatitis B markers to determine whether a person has protective antibodies from vaccination or past infection, or remains susceptible.

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Typical turnaround
1-3 business days
Starting price
From $48
Results
Confidential, online

Quick answer

This test checks hepatitis B markers in a blood sample to show whether someone is protected against the virus. It can reveal immunity from vaccination or a resolved past infection, and it can also show whether a person is still susceptible. A healthcare provider interprets the marker pattern.

What this test measures

Immunity to hepatitis B is usually reflected by antibodies against the surface antigen, known as anti-HBs. A positive anti-HBs result generally indicates protection, whether from vaccination or from recovery after infection. Core antibodies help distinguish those two situations because vaccination does not produce core antibodies.

The test uses a serum sample from a routine blood draw. Reported markers may include anti-HBs, anti-HBc total, HBsAg, and sometimes HBeAg, anti-HBe, and HBV DNA when a clinician needs to rule out current infection. The combination of markers tells a clinician whether the immune system has seen the virus and how it responded.

People order this test for school or workplace requirements, after a vaccination series, before travel, or when they want to confirm their hepatitis B protection. The report is interpreted by a qualified healthcare provider, who can advise if vaccination is appropriate.

  • Anti-HBs (hepatitis B surface antibody)
  • Anti-HBc total (hepatitis B core antibody)
  • HBsAg (hepatitis B surface antigen)
  • Anti-HBs quantitative level when included
  • HBeAg when included
  • Anti-HBe when included
  • HBV DNA by molecular testing when indicated
  • ALT (liver enzyme context)

Why people order this test

  • Confirm immunity after a hepatitis B vaccine series
  • Check protection before travel or a new job
  • Determine whether past infection has resolved
  • Identify people who remain susceptible to infection
  • Clarify hepatitis B status when records are unavailable
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How to prepare

No fasting is needed, and collection can happen at any time of day. A standard venous blood draw is performed at a laboratory. Follow the collection instructions provided by the laboratory.

Understanding your results

Results are typically reported within one to three business days. Anti-HBs positivity generally indicates protection, while additional markers help a healthcare provider determine whether immunity came from vaccination or past infection.

Hepatitis B Antibody Status Test by state

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Frequently Asked Questions

Does a positive anti-HBs mean I am protected?

In most situations, yes. A healthcare provider reviews the full marker pattern to confirm.

How is immunity from vaccination different from past infection?

Vaccination produces surface antibodies without core antibodies, while past infection typically produces both.

Should I get vaccinated if the test is negative?

That decision belongs to you and your healthcare provider, who can advise based on your risk factors.

Do I need to fast?

No fasting is required for this test.

Can the test detect an active infection?

Additional markers such as HBsAg and HBV DNA are used when an active infection needs to be evaluated.

Ready to get tested?

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Reviewed by the LabOrdering Editorial Team

Every page on this site is reviewed for clarity, sourcing, and accuracy. We update our library as testing options, collection networks, and accreditation standards change.

Medical disclaimer. The information on LabOrdering.com is educational only and is not medical advice, diagnosis, or treatment. Reference ranges and clinical guidance vary between laboratories. Always consult a qualified healthcare provider about your own results and care.