Test library
Citrus Allergy Grapefruit Test
A blood test that measures IgE antibodies to grapefruit to help identify a citrus allergy when eating or handling the fruit triggers symptoms such as itching, hives, or swelling.
Order Grapefruit Allergy Test
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order Grapefruit Allergy Test- Typical turnaround
- 1-3 business days
- Starting price
- From $49
- Results
- Confidential, online
Quick answer
This test checks a blood sample for IgE antibodies that target grapefruit proteins. It is used alongside a symptom history when someone reacts to grapefruit or other citrus fruits with itching, hives, or swelling. Results are interpreted by a qualified healthcare provider and are not a stand-alone diagnosis.
What this test measures
An allergy to grapefruit is a form of IgE-mediated food allergy, in which the immune system treats proteins in the fruit as a threat and releases antibodies and histamine. The grapefruit allergy test detects those circulating IgE antibodies in serum. Because reactions to citrus can range from mild oral itching to more significant swelling, the result is reviewed together with the symptoms and timing of exposure.
The sample required is a small venous blood draw, which is analyzed for grapefruit-specific IgE. Laboratories report the antibody level in a standardized unit and usually assign a semiquantitative reactivity class. Some panels also report total IgE and markers of cross-reactivity, since proteins shared between citrus fruits, pollens, and other plant foods can produce positive results without clinical symptoms.
People often order this test after noticing itching, tingling, or hives around the mouth after eating grapefruit or drinking citrus juice. It can also be included when a broader food allergy profile is being assembled. A healthcare provider can combine the laboratory finding with an exposure history to decide what it means for daily eating.
- Grapefruit-specific IgE antibody
- Total serum IgE
- IgE reactivity class or grade for grapefruit
- Profilin-specific IgE (pan-allergen cross-reactivity)
- Lipid transfer protein (LTP) IgE cross-reactivity
- Related citrus IgE such as orange, lemon, or lime when included
- Birch or grass pollen IgE as cross-reactive sources
Why people order this test
- Investigate itching, tingling, or hives after eating grapefruit
- Clarify whether citrus reactions have an IgE-mediated cause
- Support an elimination and reintroduction plan with a clinician
- Screen for cross-reactivity with other citrus fruits or pollens
- Add an allergen component to a broader food allergy profile
How to prepare
No fasting is required, and testing does not need to be timed around a reaction. A blood sample is collected at a laboratory. Follow the collection instructions provided by the laboratory.
Understanding your results
Results are typically available within one to three business days. A detectable IgE level indicates sensitization to grapefruit, which a healthcare provider interprets alongside symptoms, exposure history, and any other allergy findings.
Citrus Allergy Grapefruit Test by state
Alabama
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Alaska
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Arizona
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Citrus Allergy Grapefruit Test across Arkansas.
California
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Colorado
Citrus Allergy Grapefruit Test across Colorado.
Connecticut
Citrus Allergy Grapefruit Test across Connecticut.
Delaware
Citrus Allergy Grapefruit Test across Delaware.
Florida
Citrus Allergy Grapefruit Test across Florida.
Georgia
Citrus Allergy Grapefruit Test across Georgia.
Hawaii
Citrus Allergy Grapefruit Test across Hawaii.
Idaho
Citrus Allergy Grapefruit Test across Idaho.
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Frequently Asked Questions
Do I need to eat grapefruit before the test?
No. The test measures circulating antibodies, so recent exposure to the fruit is not required.
Can the test predict how severe a reaction will be?
No. Antibody levels do not reliably predict the severity of a future reaction, so clinical history remains important.
Is a blood draw required?
Yes. The test uses a serum sample collected through a standard venous blood draw at a laboratory.
Can other fruits produce a positive result?
Yes. Shared proteins among citrus fruits and pollens can create cross-reactive results that a healthcare provider can help interpret.
What should I do with a positive result?
Share the report with a qualified healthcare provider who can assess your symptoms and discuss appropriate next steps.
Ready to get tested?
Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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Every page on this site is reviewed for clarity, sourcing, and accuracy. We update our library as testing options, collection networks, and accreditation standards change.