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Crohns Disease Blood Test

This test panel evaluates blood and stool markers associated with inflammatory bowel disease, helping providers assess whether symptoms may relate to Crohn's disease.

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Typical turnaround
1-3 business days
Starting price
From $298
Results
Confidential, online

Quick answer

The Crohn's disease test panel evaluates a combination of antibody and inflammation markers associated with inflammatory bowel disease. It is intended for people with persistent digestive symptoms whose provider wants objective laboratory information. The panel does not diagnose Crohn's disease on its own and is interpreted with imaging, endoscopy, and clinical findings. Samples are collected at a partner laboratory.

What this test measures

This panel typically includes serologic markers such as antibodies to Saccharomyces cerevisiae, known as ASCA, and perinuclear antineutrophil cytoplasmic antibodies, or pANCA. Additional markers such as anti-OmpC and anti-CBir1 may be included depending on the panel. Inflammatory markers like C-reactive protein and erythrocyte sedimentation rate describe general inflammation, while fecal calprotectin reflects inflammation in the intestinal tract when a stool sample is part of the order.

Blood is collected by venipuncture, and a stool sample is collected separately when calprotectin is included. The laboratory uses immunoassays to measure the antibody and inflammation markers. Results are reported individually because patterns across markers can be more informative than any single value. For example, certain antibody patterns are more often associated with Crohn's disease, while others are more associated with ulcerative colitis, though overlap exists.

People order this testing when a provider is evaluating chronic diarrhea, abdominal pain, or other symptoms that raise concern for inflammatory bowel disease. It can also help distinguish inflammatory bowel disease from irritable bowel syndrome in some situations. The panel supports clinical assessment rather than replacing it, so a qualified healthcare provider should interpret the results alongside endoscopic and imaging findings.

  • ASCA IgG antibodies
  • ASCA IgA antibodies
  • Perinuclear ANCA (pANCA)
  • Anti-OmpC antibodies when included
  • Anti-CBir1 antibodies when included
  • C-reactive protein (CRP)
  • Erythrocyte sedimentation rate (ESR)
  • Fecal calprotectin when a stool sample is included

Why people order this test

  • Support evaluation of chronic digestive symptoms
  • Add objective markers to an inflammatory bowel disease workup
  • Distinguish patterns associated with Crohn's disease or ulcerative colitis
  • Measure general and intestinal inflammation
  • Provide data for a gastroenterology discussion
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How to prepare

No fasting is required for the blood portion of this panel. If fecal calprotectin is included, collect the stool sample according to the kit instructions and return it promptly. Tell the laboratory about medications, since some can influence inflammation markers.

Understanding your results

Results are generally available within one to three business days, though stool testing may take longer. Each marker is reported separately, and patterns are interpreted together with clinical findings. A healthcare provider should review the results, because this panel supports rather than confirms a diagnosis.

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Frequently Asked Questions

Does this test diagnose Crohn's disease?

No. It provides supportive marker information. Diagnosis requires evaluation by a healthcare provider, often including endoscopy and imaging.

What is fecal calprotectin?

It is a stool marker of intestinal inflammation that can help distinguish inflammatory conditions from non-inflammatory digestive symptoms.

Do I need to fast?

Fasting is not required for the blood tests. Follow the collection instructions if a stool sample is part of your panel.

What is ASCA?

ASCA stands for antibodies against Saccharomyces cerevisiae, a yeast marker that is more commonly associated with Crohn's disease patterns.

Can this panel rule out Crohn's disease?

No. A negative panel does not rule out the condition. A healthcare provider interprets results with the full clinical picture.

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Every page on this site is reviewed for clarity, sourcing, and accuracy. We update our library as testing options, collection networks, and accreditation standards change.

Medical disclaimer. The information on LabOrdering.com is educational only and is not medical advice, diagnosis, or treatment. Reference ranges and clinical guidance vary between laboratories. Always consult a qualified healthcare provider about your own results and care.