Test library
CA-125 Ovarian Cancer Test
The CA-125 test measures a protein known as cancer antigen 125 in the blood. It is used to help evaluate ovarian cancer and to monitor treatment, though it is not a stand-alone screening test for the general population.
Order Ovarian Cancer Blood Test
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order Ovarian Cancer Blood Test- Typical turnaround
- 1-3 business days
- Starting price
- From $158
- Results
- Confidential, online
Quick answer
The CA-125 test measures the amount of cancer antigen 125 in the blood. CA-125 is a protein that can be elevated in ovarian cancer and in several non-cancerous conditions. It is most useful for monitoring a known cancer or supporting an evaluation when symptoms or imaging raise concern, rather than as a routine screening test for everyone.
What this test measures
Cancer antigen 125 is a protein found on the surface of many ovarian cancer cells, and it can also be produced by other tissues. Its level is measured in a blood sample. Because CA-125 can rise for reasons unrelated to cancer, including menstruation, endometriosis, pregnancy, and liver or pelvic inflammation, the result is never interpreted on its own.
The test uses a blood sample drawn from a vein. Results are reported as a concentration, and clinicians compare the value with a reference range while considering the person's age, symptoms, and imaging findings. In people with a known ovarian cancer, serial CA-125 measurements can help show how the disease is responding to treatment.
CA-125 is not recommended as a general screening test for ovarian cancer in people without symptoms, because a normal result does not rule out disease and an elevated result often has a benign explanation. It is best used as one part of a broader assessment, and a qualified healthcare provider decides how the result fits into the overall picture.
- Cancer antigen 125 (CA-125)
- Ovarian cancer tumor marker level
- HE4 and ROMA score when included
- Carcinoembryonic antigen (CEA) when paired
- CA 19-9 when paired
- Additional tumor markers when a panel is ordered
Why people order this test
- Monitor treatment for a known ovarian cancer
- Support evaluation of a pelvic mass or symptoms
- Follow up on an abnormal imaging result
- Check for recurrence after treatment
- Track disease activity over time
- Provide information for a specialist discussion
How to prepare
No fasting is required for the CA-125 test. A blood sample is drawn from a vein, usually at the arm. Follow any instructions from the laboratory, especially if the test is part of a larger tumor marker panel.
Understanding your results
Results are typically available within one to three business days. The report shows the CA-125 level, which a healthcare provider interprets with imaging, symptoms, and other tests. An elevated value can have many causes and does not confirm cancer by itself.
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Frequently Asked Questions
What is CA-125?
It is a protein that can be measured in the blood. Levels may rise in ovarian cancer and in several non-cancerous conditions, so the result is interpreted with other information.
Is CA-125 a screening test for ovarian cancer?
It is not recommended as a general screening test for people without symptoms. It is used mainly to monitor known disease or to support an evaluation when there is a clinical concern.
Why can CA-125 be elevated without cancer?
Menstruation, endometriosis, pregnancy, and inflammation of the liver or pelvis are among the conditions that can raise CA-125. A healthcare provider evaluates the context.
Do I need to fast?
No. Fasting is not required for a CA-125 blood test unless it is combined with another test that calls for it.
Can a normal CA-125 rule out cancer?
No. A normal result does not rule out ovarian cancer. The test is one part of a larger clinical assessment.
Ready to get tested?
Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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