Test library
Cardiac C-Reactive Protein Test
The High Sensitivity C-Reactive Protein test measures low levels of CRP with greater precision to help assess cardiovascular risk. It is used to detect subtle inflammation that standard CRP testing may miss.
Order C-Reactive Protein Test, High Sensitivity
Order online and visit a local collection site, or choose an at-home kit where available. No referral and no insurance required.
Order C-Reactive Protein Test, High Sensitivity- Typical turnaround
- 1-3 business days
- Starting price
- From $158
- Results
- Confidential, online
Quick answer
The High Sensitivity C-Reactive Protein test, often called hs-CRP, measures C-reactive protein at very low levels. Standard CRP testing is useful for detecting active inflammation, but it is not sensitive enough to capture the small differences that relate to cardiovascular risk. This version detects those subtle differences and is interpreted with other heart risk factors.
What this test measures
C-reactive protein is a marker the liver produces in response to inflammation. Low-grade inflammation is thought to play a role in the development of cardiovascular disease, even when no obvious infection or injury is present. A high-sensitivity assay can measure CRP in the low range where standard tests lack the precision to see meaningful differences.
The test uses a blood sample drawn from a vein, and fasting is not typically required, though some laboratories prefer it when the test is combined with a lipid panel. Results are reported as a concentration, and clinicians may use them alongside cholesterol values and other cardiovascular risk factors to build a broader picture.
Clinicians order hs-CRP when they want an additional marker of cardiovascular risk, especially for people whose cholesterol and blood pressure do not fully explain their risk. It is not used to diagnose a heart attack, and an elevated result does not mean a cardiac event is occurring. A healthcare provider interprets it with the person's overall health.
- High-sensitivity C-reactive protein (hs-CRP)
- Total cholesterol when paired
- LDL cholesterol when paired
- HDL cholesterol when paired
- Triglycerides when paired
- Lipoprotein(a) when included
- Standard CRP when both are ordered
Why people order this test
- Add detail to a cardiovascular risk assessment
- Refine risk when cholesterol results are borderline
- Evaluate low-grade inflammation linked to heart health
- Follow cardiovascular risk over time
- Support a broader lipid and heart risk panel
- Provide information before discussing prevention with a provider
How to prepare
No fasting is usually required for hs-CRP, but some laboratories ask for fasting when it is paired with a lipid panel. A blood sample is drawn from a vein, typically at the arm. Follow the specific preparation instructions supplied with the order.
Understanding your results
Results are generally available within one to three business days. The report gives the hs-CRP level, which is considered alongside cholesterol, blood pressure, and other risk factors. It does not diagnose heart disease, and a healthcare provider interprets it in context.
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Frequently Asked Questions
What is the difference between hs-CRP and regular CRP?
Both measure C-reactive protein, but hs-CRP is designed to detect low levels precisely. It is used to assess cardiovascular risk, while standard CRP is used to find or monitor general inflammation.
Does hs-CRP diagnose heart disease?
No. It is a risk marker that adds information to a broader assessment. It cannot confirm or rule out heart disease on its own.
Do I need to fast?
Fasting is generally not required, unless the test is bundled with a lipid panel that calls for it. Follow the instructions provided with the order.
What can raise hs-CRP temporarily?
Recent infection, injury, or strenuous exercise can raise CRP. A clinician may suggest repeating the test when someone is well to get a steadier reading.
Should I take this test instead of a cholesterol panel?
No. Hs-CRP complements, rather than replaces, cholesterol and other cardiovascular risk tests. A healthcare provider can advise on the right combination.
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Order online and visit a collection site near you, or choose a mail-in kit. No referral and no insurance required.
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