Isocyanate HDI Antibody Test in Arizona

What this test measures

Hexamethylene diisocyanate belongs to the isocyanate family, a group of reactive chemicals used widely in industry. Polyurethane paints, varnishes, adhesives, and flexible foams are common sources. Exposure can occur during spraying, mixing, or curing, and the chemical can also be present in cured products in small amounts.

The test measures specific IgE antibodies in a blood sample. A detectable level indicates that the immune system has been sensitized to HDI, which is more common in people with repeated occupational exposure. Sensitization is not the same as a diagnosis, but it raises the likelihood that exposure is contributing to symptoms.

Workers in auto body shops, furniture manufacturing, construction, and other industries that use polyurethane products may be offered this test when they report wheezing, chest tightness, a runny nose, or skin problems that appear or worsen at work. A qualified healthcare provider should interpret the result with the exposure history and other testing.